I have noticed a burn-out effect from most amino acids after multiple days of use, especially at the often high doses that are sold.
I have not tried acetyl-l-carnitine, but I have tried similar ones like DLPA and L-Tyrosine. I find that, like psych said, I can often achieve better results by breaking open the capsules and only using 1/4 dose at a time or so. Less up and less down that way, so more consistent and long term use can be achieved. Otherwise, I go on 'runs' of a couple good days followed by cruddiness where I typically feel the need to take a break and wash out for a bit.
It's not an amino, but I found 5htp to be far too strong in normal doses of 50 or 100mg, but it is occasionally very helpful for depression/anxiety/insomnia if I pop open a capsule and take 25mg or so. Even then, I still have to take breaks because I am super sensitive to serotonin stuff...
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'......................' - What Bill Murray said to Scarlett Johansson at the end of 'Lost In Translation'