It's not entirely normal, trust me. It's not entirely abnormal, or even unexpected, but it does indicate something is going on, I think. In most cases like this, the parents are a huge part of the blame, and the child/young adult isolates themselves due to a variety of unhealthy factors. I base this on the fact he's thinking so much about it.
I really hope it does get better, and that he's able to talk to someone about it. At that age, there's always a chance of finding a better path, but if the parents aren't available for guidance, someone needs to be. This is similar enough to my boyfriend that I'm pretty concerned, and his neglect as a child was very nearly abuse, and the level of criticisms his mom gives (I had to live with her a while, I was going nuts) probably could be considered so.
If a child receives shunning from school mates, and there's usually enough support and guidance at home for him/her to remain somewhat balanced, mental pain and isolation on [I assume] the level of what is presented here is, I'm sure, much less likely to occur. It probably takes a bit more for the ASD child than normal children, of course, due to sensitivities. Anyway, this factor probably applies to quite a few posters on these forums, actually, where there's a lot of isolation and severe depression. Parental guidance through understanding, especially in adolescence, is key.