When someone addresses you, at least nod. You don't have to be their best friend, but make an effort to acknowledge someone.
If you're surfing the web in public or at school, and someone you know approaches you to say hi, look up from your effin laptop, or at least say something. Hoping they'll disappear might come across as rude, and most definitely as weird.
If someone you know comes into a social setting, acknowledge them- if you understand the language used here in this post, "hello" works, or a brief "hey" will suffice.
I hate to say it, but there's more to life than anime/video games/ sci fi channel. Broaden your horizons a little. If someone initiates a conversation that doesn't limit itself to said topics, don't cop an attitude and act offended that somebody has a life outside of your subculture.
If most of this advice seems a little obvious, you ain't the aspie demographic I had in mind. Peace.