Sure, everyone has their share of social problems, but we're not talking about existence here - we're talking about magnitude. I'm going to go with that they simply don't understand.
It's like if you were to ask someone to estimate quickly in their head how long a billion seconds is. Odds are, we'd get answers that are well off the mark in both directions.
It irked me to a great extent in high school when people - girls, most especially, would complain to friends/teachers/whoever about feeling out of place, awkward, or like losers. And then, you'd see these same people the next day around campus, with a group of Beautiful People - cute guys, attractive girls, you know the type - smiling; joking; laughing.
Simply put, if that's their idea of being lost, alone, out of place - then they don't know what it's like to be out of place. It's a logical contradiction to be laughing like that with a bunch of normal, happy people. Simply put, they wouldn't know what it's like to be unable to communicate with people, or to feel like you're on the other side of an invisible barricade - or whatever your Aspergers experience with social interaction is best described as.