I have what I call mild Aspergers. I act NT to grease the social axles. It can be difficult personally, but often it gets better results.
If I acted myself to strangers, I'd probably still be able to function in society, but good jobs or relationships may elude me. I suppress impulses, try my hardest not to shrink away from interaction, and mimic things I've seen other people do (but only after some consideration).
An extract from my blog may help to explain a little:
"I’ve been told that small talk is the social grease, and although I don’t necessarily feel the benefits of it, it gives the illusion of being ‘normal’. It’s a shame, but some NTs might feel awkward around people who don’t conform, and an uncomfortable NT may be more difficult to interact with. So when someone says to me “it’s a right cold patch we’re having isn’t it?”, I don’t just say “yes” and move on, I try to say something like “well I hear it will get better by Monday”. Just that small stock sentence may illicit a smile from the other party, because there is that expected bit of social grease that tells them they’re not dealing with a psychopath, oddball, or any other type of weirdo. Okay, I still often come across as socially awkward by dint of inflection or odd pause lengths in conversation, but they appreciate it. Think of it like speaking bad French to a Frenchman – he might pick up on it, but will appreciate you trying."
In short, I think a decent effort makes it much easier to interact with NTs. Of course, people further along the spectrum will find this harder.