Well, I'm from Chicago and I love my home. There's always plenty to do and great food. The downside is you might be murdered. (Seriously. Crime has gotten ridiculous.)
I live near St. Louis now and I actually really like it. It's not too busy and there's always a lot of events going on. Plus it has one of the biggest free zoo's in America if you're into that sort of thing.
I read that St. Paul, MN is very ASD friendly and has a good public transit system. I've never been there, though.
No matter where you decide to go, make sure you visit beforehand. 