Instead of "2001: A Space Odyssey", Kubrick worked on an earlier version of "A Clockwork Orange", which was panned by critics and never won an award. Heartbroken, Kubrick committed suicide. "2001" was never produced, and most SF movies from then on continued in the "Monster From Out There" genre well past 2020, thus almost killing the genre.
For instance, "Star Wars" was about a cryogenically frozen Wookie whose prison ship crash-lands near Los Angeles, and he is chased by neo-nazi survivalists (who can't shoot straight) until an orphaned farm boy (played by Mark Hamill) befriends the alien creature and takes him to the north woods, dodging those same neo-nazi survivalists (who can't still shoot straight) and always remaining one step ahead of a governmental MIB named Dirk Baker, who turns out to be the farm boy's real father. Along the way, they meet a wise old homeless grifter who does card tricks, a spoiled 'princess' from Bel Aire who can butt-kick anyone senseless, a pair of stoners (one speaks only in chirps and whistles, and the other talks too much), and a grizzled old trucker who always shoots first. Much hilarity ensures.
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The mere fact that science may not yet adequately explain an object, event, or experience does not mean the immediate explanation should automatically default to a conspiratorial, extraterrestrial, paranormal, or supernatural cause.