Depends on the autistic.
If one is conditioned to value what NTs tend to value, they'd be subject to feelings of rejection and insecurity by tying said values into survival and self worth. Which usually leads to anxiety and depression...
Looking further away, this is somewhat akin to creating a problem that shouldn't exist in the first place -- because this particular issue is actually learned, not merely because most people are humans with social needs; tho that aspect doesn't help. This main counter against this is usually unlearning the BS...
If their primary struggles are executive function and daily living instead of just the emotional and socialization aspects, definitely will make someone else's life harder, NT majority or no.
Which leads to anxiety and depression, definitely, unless one does not mind to be dependent or even helpless for most of their life, likely at mercy of someone else who do not struggle with it.
Or in state of constant uncertainty alone out of sheer lack of self control, intolerance, or dysregulation, which itself can foster a lot of suffering as an autistic -- unless the autistic has an insane amount of tolerance to uncertainty, ambiguity, and chaos with their lack of self control and direction.
Maybe AuDHD itself is a coping mechanism or a counter for that for some reason.