Creatine + Fluoxitine (Prozac)

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I have been diagnosed as having Aspergers since I was about 7 or 8.

I have have started taking Fluoxetine in the last month and a half which I have found has really helped me when it comes down to processing my thoughts and vocalizing my thoughts. Its quite good medication apart from that I feel that it is causing my heart rate to by quite high at times and it is giving me a dry mouth.

I've recently bought a kg of Pro Power Creatine powder and planned on starting using it next week after I focus on a bit more cardio.

What I am asking is, does anybody know if there is any possibility of adverse effects from taking the two together?

Thanks

I doubt it

Thanks man.

Can anyone else back that up?

I did read one thing about it and someone said (from an unofficial source) "if you take the anti-depressant Prozac, Sarafem, or fluoxetine, DO NOT take creatine, as Prozac will elevate levels of creatine phosphokinase, one of the metabolites of creatine in certain people."

Can somebody please tell if that is true and is it something I need to be worried about?

I dont know about what reaction with Prozac it would cause but I refuse to take creatine. It has been researched to be safe but all it does is cause your muscles to become filled with water. If you want to get a natural source of creatine then eat red meat.

I take whey protein while weightlifting or doing cardio. There are numerous benefits from using it. http://en.wikipedia.org/wiki/Whey_protein Its also fairly cheap at $0.75 a serving. Currently I am taking 100% Natural Oats and Whey by Optimum Nutrition, its real good stuff.

Unfortunately it is near impossible to fill muscles with creatine through meat alone. Per KG of muscle we hold only a gram or so of creatine (off the top of my head). The maximum we can get through supplementation is 20g per 1kg.

To get this through eating meat you would need to eat way more than what is safe for our bodies to digest.


I am gonna take a look at that whey protein and see if i can find a good deal on it in the UK though Thanks man!

So anyone know much about Creatine Phosphokinase or got any detailed links? I've had a little bit of a look about online but I can't find anything good.

I took creatine and prozac together for almost a year and I now have gait, hair growing out of my tear ducts, cheesy armpits, ...Naw, just joking, you'll be fine.

I am curious as to what the source is. Creatine phosphokinase is not a metabolite; it is an enzyme that catalyzes the transfer of phosphate between ATP and creatine. In clinical use this enzyme is used to evaluate muscle injuries, as it is in high concentration in striated muscle fibers. In this context one problem with SSRIs is the potential to infterfere with pituitary activity, which could effectively lower androgens, estrogens, and thyroid hormones.

I too would have to review the evidence on creatine supplementation; it hasn't been my most pressing concern as of late. What I recall reading about is an increased potential for muscle injury with creatine supplementation, hence a possible creatine phosphokinase increase.

First and foremost should be a healthy body, IMO.

Okay, straight out of PubMed.

Research involving creatine kinase in rat brains:
http://www.ncbi.nlm.nih.gov/pubmed/19772902

Rhabdomyelosis associated with SSRI and strength training:
http://www.ncbi.nlm.nih.gov/pubmed/16960512
No cause and effect relationship is clear from the abstract.

I never got any results with creatine I cannot attribute to exercise and diet alone. I really think it is all a bunch of bunk. I have tried it more than once too and all I did was waste money. I would advise upping your protein intake, cut down on processed carbs and make sure you get enough healthy fat in your diet. Spend that money on good nutritious foods and you can be sure of results- you cant be sure of them with supplements.

I'm noticing slight improvements from it plus I want to start taking Ribose with it as well.

Have a read of this:

http://www.bodybuildingforyou.com/suppl ... -stack.htm

Its your money, and this article is pretty much there to get you to buy the linked products they are reviewing. I would just wonder of your change in diet really got your results rather than the creatine. When people start to lift weights or do any types of exercise program they usually also change their diet.

I'm not a doctor or chemist, but I do have personal experience with taking creatine (capsules) and Fluoxetine (10mg/day). No issues at all, that I know of, or that my doctor spoke of.

The only thing I've read about Creatine, is that in some people, it can "shorten your fuse", or make you a little more likely to get angry. I haven't experienced that either, and I'm Irish.

Charles

You could always check interactions at some sites too


Here are a couple
drug interaction calculator

healthline interaction checker I really like this one because it is more user friendly IMO, but the other one is fine too

Neither checker found any interactions, just so you know, but I thought this would be handy to anyone reading the thread. You should always check your prescriptions along with OTC meds like allergy meds and pain relievers or vitamins and supplements. There are even interactions with common foods sometimes. The second checker I linked will give you information on any one drug as well- not just the ones you add together.

if you're only doing cardio you're not going to gain much from creatine. creatine is useful for short bursts of power, like when you're lifting weights or sprinting. the thing is that after about 10sec of intense exercise, like a 100m sprint, your muscles are depleted of creatine, so for the rest of your cardio session you're simply using fat/glycogen stores for your energy. if you're not sprinting then it might last longer, say 1-2mins, but after that it's useless. i've rowed for about 5 years now and every race goes the same way, a 2km race will start off hard and you won't really feel any pain for about 20-30sec but after that you can feel your muscles using up their energy stores and within 1min your muscles are filling with lactic acid. a 5k race is a little slower, you might not feel the burn until 2mins in but your creatine reserves are long gone by then.

now weight training is a completely different issue. creatine can increase your maximum power and can help you lift more weight for more reps thus making your workouts more effective. strength training can, in turn, positively affect your cardio but creatine on its own won't really do much more than give you soggy muscles and make you think you're faster.

I have taken fluoxetine at relatively high doses (60mg/day) for 20+ years.

When I am starting as mass cycle, I take 5gm creatine 5X/day for 7 days and 5gm/day thereafter.

I've not sprouted any extra limbs/nipples/etc and my metabolic parameters have been text-book normal since I began strength training.

Creatine has noticably improved my gains and speeded recovery and I intend to keep using it.

If I suddenly drop dead, I'll be sure to let you know...