I think it might be possible, too many forget that being a free thinker doesn't mean you need proof to consider a --possibility--. I mean energy is a relatively new and not very well understood field of science, if a soul or even black magic exists, it would be about energy flow and energy mechanics, and most people who practice magic (I'm not talking about the wanna-be's) will explain magic as energy flow, they'll also tell you that you can't use to perform "divine miracles" and that all of that thinking of magic is hollywood condtioning.
Consider that they set spells according to the phases of the moon, our moon holds the tides, and our bodies are made up mostly of water... When the tides come in, there is a slight gravitational pull coming from our bodies towards the tides that we do not feel. Perhaps this is the road where spells work on?
Like I'm saying, it's all possibility, I'm not stating it as fact. Science is the basis of what can be determined truth, for it is science that seeks answers and evidence. Lets not limit science, it has not peaked yet.