GABA has changed my life :)

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I will have to bing alpha brain.

do so. Its prerry decent. Doesnt have any speedy effects like coffee, you dont feel anything per say when you take it. Ive noticed it helps me leave the house without forgetting anything. Some times I get behind the wheel 2 or 3 times and have to go back in the house because I realize I forgot something.

Helps me focus in on my task and go longer without getting distracted to! My verbal speech(speaking and listening) feels a little better on it to. Kind of expensive tho

Well im off to the store to go get some GABA now

k so I tried some GABA today. I feel the fk asleep for most of the day. LOL feel ok now tho. I think with a coffee or redbull it wouldnt make you fall asleep but I was not expecting that.

I do feel pretty good right now.

I do drink coffee until early evening, I think you are right about the effect of adding it, sorry, it hadn't occurred to me.

When I go to bed now I can fall asleep within a couple of minutes. Before GABA it could take me anything from 45 mins to 4 hours. And I seem to sleep much more deeply, wake up with more mental clarity. Be interested to hear if others experience this too.

Hmm it was all sounding pretty good until the last three posts. I have hypersomnia and I don't drink coffee/energy drinks. I don't need anything to make me more sleepy than I already am!

DevKit is it still going well?

I learned today that GABA deficient brains = sleep, but don't have the same level of theta cycles during sleep (these are the deep restful brain cycles during sleep). If you aren't getting these, it's possibly the case that you will be extra tired - and wanting to get more and more sleep. But additional sleep doesn't address the deficiency. Have a look at the reviews (online) of a book called The Edge Effect - more information.

Interesting. But do you mean delta wave cycles, not theta? The delta waves appear during stages 3 and 4 which I thought were the most deep/restful.

I have spent the night in a sleep lab but they said there was nothing wrong with my sleep cycle. However, I am ALWAYS dreaming. Whenever I wake up, I am in the middle of a dream. I know you can dream during any stage of sleep but it still seems unusual to me. I can't figure out how this could relate to a bad sleep cycle, though, as you have to get through the first four stages before you get to the main dreaming stage.

Anyway, thanks for the info. Food for thought.

Read this analogy on the net:

" GABA is the groom who takes those horses out to pasture to munch on the green grass and rubs the horses down with a nice brush. In the right balance, you have a winning horse. With too much excitatory action you get a worn-out old nag.
The writer adds:
In autistic spectrum disorders, there are a number of lines of evidence pointing to problems with the excitatory/inhibitory balance in the brain. There seem to be increases in expression of RNA for genes in the glutamate pathway, and there are certain genes having to do with the glutamate system that increase the risk for having autism. Glutamate is actually the precursor for GABA, and the enzyme that catalyzes the transformation from one to the other is glutamic acid decarboxylase. Both reduced levels of this enzyme and increased levels of glutamate have been reported in areas of the brain and spinal fluid in some children with autism."

Maybe the day is coming when ASD diagnosis will not be behaviourally inferred but diagnosed directly from biological testing in some highly refined form.

Interesting brain imaging study regarding GABA:

Google: "Imaging shows loss of brain chemical in autism"

I live on GABA. I carry they with me to work. Up to several times per day, I pop one under my tongue and it helps me through the tough times. There is also a Valerian Stress formula that I take in first thing in the morning to help me start the day which for me can be the hardest time. One warning: do not take Valerian with alcohol ever! My wife did prior to drinking a glass of wine. It put her away. Later I read the warning and saw that it should never mix with alcohol. I am not sure about mixing GABA and alcohol however.

GABA is good.

Hi DCGSage.

My huge improvement on GABA continues, and it's been so dramatic that I now think of taking it as being analogous to a type 1 diabetic taking insulin. I would never stop taking it now.

In a nutshell, GABA allows me to function as the best version of me. It vanquished crippling anxiety that kept me alone and miserable at home, too anxious to go out a lot of the time, very uptight when I did, and this was complicated by some post trauma after getting mugged last year. Then I took GABA, it was like the prison door sprang open and I was FREEEEEEEEEEE!! !!

I don't take valerian although in the past I tried it - not good (threw up) - maybe it was the formulation or something in it I was allergic to, not sure, though the experience put me off for good!

And your caution is wise re alcohol (I don't drink anyway) because no substance with sedating properties goes well with it. It can magnify the effect and not in a good way.

Some questions if you don't mind?

-How long have you been taking GABA?
-Did you notice immediate improvement?
-What has changed the most for you with it?
-How much do you take? (Mg)

Good to hear from you.

However, there is also more scientifically and medicinally relevant evidence that pure GABA does not cross the blood?brain barrier at therapeutically significant levels.[40] The only way to deliver GABA effectively is to circumvent the blood-brain barrier.

40. https://www.ncbi.nlm.nih.gov/pubmed/556 ... t=abstract

Picamilon and Phenibut may solve that and were dev. by the USSR

Yes, the blood/brain barrier is a fascinating issue.

There is a lot of interesting comment about GABA being able to enter the CNS directly, rather than across the barrier, and various views.

Also this article mentions how/why GABA may affect men and women differently: A Biochemist's Experience with GABA - P J Bronson

Whether it did cross my bb barrier, or entered through the CNS system, or whatever, the results are the same for me - an astonishing transformation of mood, energy, motivation, emotional states etc all for the better, and this is not a placebo effect.

Pramod Dash from the University of Houston wrote this in an article on the bbb too - it was very surprising to me to learn that only some of the brain has the barrier... and perhaps would surprise not only most people but most doctors..(?)


Quote from Dash:
All areas of the brain do not have a blood-brain barrier. The structures located at strategic positions in the midline of the ventricular system and lack the BBB are collectively referred to as circumventricular organs (CVOs). In these non-barrier regions, the tight junctions between endothelial cells are discontinuous thus allowing entry of molecules. Many of these areas participate in hormonal control.

Areas of brain without a blood-brain barrier:

?Pituitary gland
?Median eminence
?Area postrema
?Preoptic recess
?Paraphysis
?Pineal gland
?Endothelium of choroid plexus
End of quote.

The plot just thickens and thickens....!

I began taking GABA even before I suspected I might have high functioning autism. My wife used GABA to get off from her addiction to anti depressants. I was having a hard time at work when my job began to get complicated. I was not handling things well at all...almost a walking nervous breakdown waiting to happen. I told my wife I might need anti depressants to cope. She put me onto GABA, telling me to stick one under my tongue when I felt the stress levels begin to rise. I was taking them nearly 3 times per day to get through it.

For me, it seemed to take about 20 min to begin to calm me down.....It just seems to settle my mind. My aspergers gets my mind rolling out of control and when it does, I have a heck of a time doing any task. What it did is allow me to focus better on the task I was doing. Before I would be doing tasks without thinking about them....my mind buzzing off in other directions.

Now I don't need as much but I take about one per day just before I know I might be in a stressful situation or task at work or in a private setting. I also take one before I go to bed on work nights. And even though I have been married to my wonderful wife for 22 years, now and then, I take one before intimacy. Now and then I have a hard time getting focused before sex....I think it helps blood flow...maybe....but that might be TMI. Sorry.